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BDNF’s most remarkable effect is also its most contentious. Years of research show that, at least in rats and mice, exercise-induced BDNF triggers the growth of new brain cells in the hippocampus, a process called neurogenesis. BDNF does this by boosting the function of stem cells in the brain, eventually filling the hippocampus with new healthy cells that enhance brain power.

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Whether neurogenesis also happens in adult humans is more controversial. Some studies suggest yes, others no. That’s because there’s no clear way to measure the birth of a new brain cell without cutting open someone’s skull.

“Until there are better, more sophisticated methods that directly address whether neurogenesis is increased by exercise in humans, that remains unclear,” says Henriette van Praag, an associate professor of biomedical science at Florida Atlantic University.

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