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Every time you work out, your muscles, fat cells, and liver release a variety of molecules into the bloodstream. Some of these molecules circulate through the body and travel up to the brain, where they cross the blood-brain barrier. Once inside, they trigger a cascade of beneficial changes that can make you feel sharper and happier.

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One of the most crucial changes is the release of a growth hormone called brain-derived neurotrophic factor, or BDNF. When it comes to exercise’s positive effects on the brain, BDNF is the star.
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