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Exercise also changes the brain’s network of blood vessels. More blood flow in the body from exercise corresponds to more blood flow in the brain, as well as the rise of a blood vessel-specific molecule called vascular endothelial growth factor (VEGF). As a result, new blood vessels form in the hippocampus. In rodent brains, neurogenesis and blood flow are connected, potentially because the new blood vessels bring more growth factors to the area. Humans experience the same increase in blood vessels, providing another clue that neurogenesis may be occurring in people.

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Anyone who’s felt a “runner’s high” — or just felt less crappy after a workout — has experienced the way exercise elevates neurotransmitters like serotonin, dopamine, and endogenous opioids (also known as endorphins), which are critical for regulating mood, motivation, and feelings of reward. Researchers are less clear about how these changes start — although, like everything else, they appear to be connected to BDNF. It’s possible that these neurochemicals go up simply because exercise is rewarding. Anything that makes you feel good will raise your dopamine levels, for example, so if going to a SoulCycle class is fun for you, your brain will release the reinforcing chemical in response.

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